Immunohistological Analysis of Lichen Sclerosus of the Foreskin in Pediatric Age: Could It Be Considered A Premalignant Lesion?

Background: A major worry of juvenile penile LS is potential malignant degeneration to spinocellular carcinoma (SCC) in adulthood. characterized by increased CD8+ and CD57+ cells, dermal sclerosis, epidermal atrophy, hyperkeratosis. p53 Ki67 are reliable premalignant markers. Our aim was define the immunohistochemical profile foreskin children, focusing on tissue immune response cell proliferation. Methods: Thirty specimens foreskins removed from pediatric patients during circumcision were included: six ritual operation (A), twelve phimosis (B), with (C). Formalin-fixed paraffin-embedded sections stained for histomorphology immunohistochemistry. quantitative evaluation CD8, CD57, p53, Ki-67 a statistical analysis performed. Results: As compared groups B, samples group C showed an acanthotic epidermis, band lymphoid infiltrate significant enhancement lymphocytes, keratinocytic hyperplasia overexpression Ki67+ p53+ cells. Conclusions: Immunohistological findings confirmed reaction proliferative behavior foreskin. We believe that radical should be first treatment choice clinical suspicious risk transformation SCC